RNA Structure and Stability |
| |
| Institution: | 1. Division of Hematology and Oncology, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA;2. Division of Hematology and Oncology, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA;3. Division of Cytogenetics, LabCorp, Center for Molecular Biology and Pathology, Research Triangle Park, NC, USA;4. Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA;5. Pathology and Laboratory Medicine Service, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA;1. Department of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM), Santa Maria, Brazil;2. Department of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Chapecó, SC, Brazil;1. College of Chemistry and Molecular Sciences, Institute of Advanced Studies, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, Hubei Province 430072, China;2. Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei Province 430071, China;3. Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, Hubei Province 430071, China;1. The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;2. RIBOMIC Inc., Minato-ku, Tokyo 108-0071, Japan;1. School of Agriculture and Food, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Victoria 3010, Australia;2. Incitec Pivot Fertilisers, Seabreeze Parade, North Shore, Victoria 3214, Australia;3. PBL Netherlands Environmental Assessment Agency, The Hague, The Netherlands |
| |
| Abstract: | RNA molecules fold into specific base-paired conformations that contain single-stranded regions, A-form double helices, hairpin loops, internal loops, bulges, junctions, pseudoknots, kissing hairpins, and so forth. These structural motifs are recognized by proteins, other RNAs, and other parts of the same RNA. The interactions of these structural elements are crucial to the biological functions of the RNA molecules. We describe the different motifs and discuss their thermodynamic stabilities relative to single strands of RNA. The stabilities determine under what conditions they occur and whether they change when interacting with proteins or other ligands. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
