RNA Signals in Entero- and Rhinovirus Genome Replication |
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| Affiliation: | 1. Virology Laboratory, University Hospital, Dijon, France;2. Epidemiology and Infection Control Unit, University Hospital, Dijon, France;1. Institute of Green Chemistry and Chemical Technology, School of Chemistry & Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China;2. School of Energy and Power Engineering, Jiangsu University, Zhenjiang 212013, PR China;3. Jiangsu Fluid Machinery Engineering Research Center, Jiangsu University, Zhenjiang 212013, PR China;1. Tufts University School of Medicine, Department of Public Health and Community Medicine, 136 Harrison Avenue, Boston, MA 02186, USA;2. Tufts University, Departments of Occupational Therapy and Community Health, 574 Boston Avenue, Suite 216, Medford, MA 02155, USA |
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| Abstract: | The VPg-linked, plus-stranded RNA genomes of entero- and rhinoviruses contain very different 5′ and 3′ terminal regions which harbor signals for RNA replication. The terminal cloverleaf-like structure of the 5′-nontranslated region (5′NTR) is known to be required for plus-strand RNA synthesis. Genetic evidence suggest that two stem-loop structures and the poly(A) tail of the 3′NTR have a function in minus-strand synthesis. All of the nonstructural viral proteins, and possibly also some cellular polypeptides, are believed to be involved in RNA replication. RNA synthesis is initiated on a poly(A) template and involves uridylylation of VPg to yield VPgpU(pU). This precursor is likely to serve as primer for the RNA polymerase 3Dpolduring both minus- and plus-strand RNA synthesis. |
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