Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System |
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Authors: | Liandong Hu Yanjing Shi Jian Heng Li Na Gao Jing Ji Feng Niu Queting Chen Xiaoning Yang Shaocheng Wang |
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Institution: | 1. School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People’s Republic of China 6. Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, People’s Republic of China 2. Department of Hematology, Affiliated Hospital of Hebei University, Baoding, People’s Republic of China 3. CSPC Pharmaceutical Group NBP Pharmaceutical Co. Ltd, Shijiazhuang, People’s Republic of China 4. Department of Surgical Oncology, Affiliated Hospital of Hebei University, Baoding, People’s Republic of China 5. Tianjin Hemay Bio-Tech Co., Ltd, Tianjin, People’s Republic of China
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Abstract: | The objective of this study was to improve the solubility and bioavailability of curcumin by a new curcumin dripping pills (Cur-DPs) formulation using melt mixing methods. The optimal formulation consisted of Polyethoxylated 40 hydrogenated castor oil (Cremophor RH40), Poloxamer 188, and Polyethylene glycol 4000 (PEG 4000). Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FT-IR) were used to verify the forming of Cur-DPs. All the physical characterization information proved the formation of Cur-DPs, and the results demonstrated the superiority of the dripping pills in dissolution rates. The pharmacokinetic study of Cur-DPs was performed in rats compared to the pure curcumin suspension. The oral bioavailability of poorly water-soluble curcumin was successfully improved by CUR-DPs. And the stability of prepared Cur-DP was also in a good state in 3 months. These results identified the Cur-DPs was an effective new approach for pharmaceutical application.KEY WORDS: curcumin, dripping pills, oral bioavailability, physicochemical properties, stability |
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