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A Mathematical Model of Chlamydial Infection Incorporating Movement of Chlamydial Particles |
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| Authors: | Dann G. Mallet Masoumeh Bagher-Oskouei A. Charisse Farr Daniel P. Simpson Kelly-Jean Sutton |
| Affiliation: | 1. Mathematical Sciences School, Queensland University of Technology, GPO Box 2434, Brisbane, Qld, 4001, Australia 2. Institute of Health and Biomedical Innovation, Queensland University of Technology, GPO Box 2434, Brisbane, Qld, 4001, Australia 3. Biotechnology and Bioengineering Centre, Medical College of Wisconsin, Milwaukee, USA 4. Department of Mathematical Sciences, Norwegian University of Science and Technology, Trondheim, Norway 5. School of Mathematical Sciences, University of Nottingham, Nottingham, UK 6. Department of Infectious Disease Epidemiology, Imperial College London, London, UK |
| Abstract: | We present a spatiotemporal mathematical model of chlamydial infection, host immune response, and movement of infectious particles. The resulting partial differential equations model both the dynamics of the infection and changes in infection profile observed spatially along the length of the host genital tract. This model advances previous Chlamydia modelling by incorporating spatial change. Numerical solutions and model analysis are carried out, and we present a hypothesis regarding the potential for treatment and prevention of infection by increasing chlamydial particle motility. |
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