Globo-A--a new receptor specificity for attaching Escherichia coli |
| |
Authors: | D Senior N Baker B Cedergren P Falk G Larson R Lindstedt C S Edén |
| |
Institution: | Department of Clinical Immunology, University of G?teborg, Sweden. |
| |
Abstract: | Uropathogenic Escherichia coli strains designated as ONAP, based on their O negative A positive agglutination of human P1 erythrocytes, were shown to prefer the globo-A glycolipid as a receptor structure. The dependence on both the A terminal and the globoseries chain was confirmed by agglutination of human AP1, but not Ap or OP1 erythrocytes and by binding to the globo-A glycolipid on TLC plates. Neither Gal alpha 1----4Gal beta nor the A trisaccharide GalNAc alpha 1----3(Fuc alpha 1----2)Gal beta alone functioned as receptors. The bacteria thus appeared to recognize an epitope resulting from the combination of the terminal and internal structures. |
| |
Keywords: | |
|
|