| 刺激中缝背核和蓝斑对下丘脑弓状核区诱发电位的影响 |
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| 引用本文： | 端木肇夏
,张跃进
,张惠琴
,印其章.刺激中缝背核和蓝斑对下丘脑弓状核区诱发电位的影响[J].生理学报,1985(6). |
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| 作者姓名： | 端木肇夏 张跃进 张惠琴 印其章 |
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| 作者单位： | 苏州医学院生理教研室，苏州医学院电生理研究室 |
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| 基金项目： | 中国科学院基金委员会资助(82年科生准字第100号) |
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| 摘 要： | 实验在用水合氯醛麻醉的雄性成年大鼠上完成。目的是观察刺激中缝背核和蓝斑对刺激坐骨神经诱发下丘脑弓状核区电位的影响。结果表明:(1)电刺激中缝背核和蓝斑与腹腔注射吗啡一样,可以明显抑制外周伤害性刺激所诱发的弓状核区电位的第三个迟发成分(Sw_3);(2)脑室注射及微电泳作为中缝背核和蓝斑各自所释放的主要神经递质——5-羟色胺和去甲肾上腺素也能明显地抑制 SW_3成分。
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| 关 键 词： | 诱发电位 下丘脑弓状核 伤害性刺激 吗啡 中缝背核 蓝斑 5-羟色胺 去甲肾上腺素 微电泳 |
EFFECT OF RAPHE DORSALIS AND LOCUS COERULEUS STIMULATION ON EVOKED POTENTIAL IN HYPOTHALAMIC ARCUATE NUCLEUS AREA |
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| DUANMU ZHAO-XIA,ZHANG YUE-JIN,ZHANG HUI-QIN,YIN QI-ZHANG.EFFECT OF RAPHE DORSALIS AND LOCUS COERULEUS STIMULATION ON EVOKED POTENTIAL IN HYPOTHALAMIC ARCUATE NUCLEUS AREA[J].Acta Physiologica Sinica,1985(6). |
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| Authors: | DUANMU ZHAO-XIA ZHANG YUE-JIN ZHANG HUI-QIN YIN QI-ZHANG |
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| Abstract: | Experiments were performed in adult male rats anesthetized with chloral hy-drate.The purpose was to observe the effect of raphe dorsalis(DR)and locus coeru-leus(LC)stimulation on potential evoked in hypothalamic arcuate nucleus(ARC)area by sciatic nerve stimulation.The results show that:(1)electrical stimulation ofDR or LC,similar to intraperitoneal injection of morphine,could,significantlyinhibit the third slow wave component(SW_3)evoked in ARC area by peripheralnoxious stimulation;(2)intravcntricular injection and microiontophoresis of 5-hydroxytryptamine or norepinephrine,main neurotransmitters released from ter-minals of DR or LC neurons,respectively,could also inhibit SW_3 component. |
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| Keywords: | evoked potential hypothalamic arcuate nucleus noxious stimulation morphine raphe dorsalis locus coeruleus 5-hydroxytryptamine norepinephrine microiontophoresis |
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