|
|||||
|
|
Lyophilization stabilizes clinical-stage core-crosslinked polymeric micelles to overcome cold chain supply challenges |
|
| Authors: | Tarun Ojha Qizhi Hu Claudio Colombo Jan Wit Michiel van Geijn Mies J. van Steenbergen Mahsa Bagheri Hiltrud Königs-Werner Eva Miriam Buhl Ruchi Bansal Yang Shi Wim E. Hennink Gert Storm Cristianne J. F. Rijcken Twan Lammers |
| Affiliation: | 1. Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University, Aachen, Germany Department of Pharmaceutics, Utrecht University, Utrecht, The Netherlands Department of Medical Cell BioPhysics, Faculty of Science and Technology, University of Twente, Translational Liver Research, Enschede, The Netherlands;2. Cristal Therapeutics, Maastricht, The Netherlands;3. Saudade Pharma Consultancy, Eijsden, The Netherlands;4. Department of Pharmaceutics, Utrecht University, Utrecht, The Netherlands;5. Electron Microscope Facility, University Hospital RWTH, RWTH Aachen University, Aachen, Germany;6. Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University, Aachen, Germany Department of Medical Cell BioPhysics, Faculty of Science and Technology, University of Twente, Translational Liver Research, Enschede, The Netherlands;7. Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Faculty of Medicine, RWTH Aachen University, Aachen, Germany;8. Department of Pharmaceutics, Utrecht University, Utrecht, The Netherlands Department of Biomaterials, Science and Technology, Faculty of Science and Technology, University of Twente, Enschede, The Netherlands |
| Abstract: | |
| Keywords: | drug delivery lyophilization nanomedicine polymeric micelles tumor targeting |