| Institution: | 1. Learning Key Laboratory for Pharmacoproteomics, Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China
Jiayin Gao and Jialong Yan contributed equally to this study.;2. Learning Key Laboratory for Pharmacoproteomics, Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China |
| Abstract: | N6-methyladenosine (m6A) is one of the most common internal modifications in messenger RNA, which is necessary for cell physiological activities. A recent study shows that during mammalian hematopoietic development, loss of m6A modification leads to the aberrant production of double-stranded RNA, which results in the abnormal activation of innate immune response, and ultimately leads to hematopoietic failure. Accordingly, m6A modification provide us an attractive direction for us to understand mammalian hematopoietic development and innate immune response. |
