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Two New Alkaloids from Fuzi and Their Metabolites Study |
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| Authors: | Sisi Liu Pei Deng Yihong Long Shushu Yang Junshuo Zhu Kunsheng Li Changjiangsheng Lai Weiran Yang Jinlong Chen |
| Institution: | 1. School of Resources Environmental & Chemical Engineering, Nanchang University, Nanchang, 330031 China
These authors contributed equally to this work.;2. Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China These authors contributed equally to this work.;3. School of Resources Environmental & Chemical Engineering, Nanchang University, Nanchang, 330031 China;4. Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China;5. State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700 China |
| Abstract: | Former study suggests alkaloids from herbs of Aconitum genus plants possess excellent bioactivities, which exert great value for related deeper chemical constituent investigation. Herein, chemical isolation was performed and four alkaloids were isolated from Fuzi, of which two were new ones, and the other two were reported NMR data for the first time. Their chemical structures were identified by NMR data, high resolution MS, UV and IR analysis. Additionally, the MS fragmentation patterns were explored, formerly, that of hetisane alkaloid was rarely reported, and fragmentation mechanism of the diagnostic ion was proposed. Based on these fragment pathway, metabolites and metabolic pathways of four compounds were investigated in rat liver microsomes using UPLC−Q/TOF−MS, and dehydrogenation product was firstly found from metabolites of hetisane alkaloid. |
| Keywords: | Fuzi hetisane alkaloid fragmentation pattern metabolite |