The biological characteristics of the canine adenovirus type 1 from fox and the transcriptome analysis of the infected MDCK cell |
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| Authors: | Yanzhu Zhu Jie Sun Minghao Yan Shizhen Lian Bo Hu Shuang Lv Yali Li Yufei Zhang Xijun Yan |
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| Affiliation: | 1. Key Laboratory of Special Animal Epidemic Disease, Ministry of Agriculture, Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China;2. Pharmaron Beijing Co., Ltd., Beijing, China;3. Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China;4. National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China |
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| Abstract: | Canine adenovirus type 1 (CAdV-1) is the etiologic agent of fox encephalitis, and a virus strain from fox encephalitis is isolated and related research are conducted. In this experiment, the results showed that the F1301 strain was confirmed to be the CAdV-1. The whole genome of the CAdV-1 F1301 strain isolated from fox was 30,535 bp and had higher homology to the other reported CAdV-1 strains. After 0, 12, and 36 h of CAdV-1 infection, the difference gene of the 592 long noncoding RNA and 11,215 microRNA were involved in cell responses to CAdV-1 infection through the PI3K-AKT, Wnt, Herpes simplex, hepatitis C, and Epstein–Barr virus infection pathway in Madin–Darby canine kidney cell line (MDCK). The results indicate that the biological characterization of the CAdV-1 and the MDCK cell-CAdV-1 interaction are clarified. |
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| Keywords: | biological characterization canine adenovirus 1 MDCK cell transcriptome analysis |
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