Three New Hydroxyphenylacetic Acid Derivatives and A New Alkaloid from Endophytic Fungus Mortierella sp. in Epimedium acuminatum Franch. and Their Antibacterial Activity |
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| Authors: | Ze-Diao Huang Wen-Jing Wang Xiao-Le Han Xiao-Long Yang |
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| Institution: | 1. The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074 P. R. China;2. Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science, South-Central University for Nationalities, Wuhan, 430074 P. R. China |
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| Abstract: | Three new hydroxyphenylacetic acid derivatives, stachylines E-G ( 1 – 3 ), and a new alkaloid, mortieridinone ( 4 ), along with six known compounds ( 5 – 10 ), were isolated from endophytic fungus Mortierella sp. in Epimedium acuminatum Franch. Their structures were determined by their spectroscopic analyses and by comparison with the literature data. Compounds 7 and 10 showed selective antibacterial activity against tested multidrug-resistant bacteria with minimum inhibitory concentration (MIC) values ranging from 25 to 3.13 μg/mL. |
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| Keywords: | Mortierella sp Epimedium acuminatum hydroxyphenylacetic acid oxysporidinone antibacterial activity |
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