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A Review on Metabolites from Onchidium Genus: Chemistry and Bioactivity |
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| Authors: | Bowen Wang Deli Chen Meng Yu Yangyang Liu Pinghuai Liu Xiaopo Zhang |
| Affiliation: | 1. School of Chemical Engineering and Technology, Hainan University, Haikou, 570228 P. R. China Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences & Peking Union Medical College, Haikou, 570311 P. R. China These authors contributed equally to this work.;2. Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences & Peking Union Medical College, Haikou, 570311 P. R. China;3. Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences & Peking Union Medical College, Haikou, 570311 P. R. China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193 P. R. China;4. School of Chemical Engineering and Technology, Hainan University, Haikou, 570228 P. R. China;5. Key Laboratory of Tropical Translational Medicine of the Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199 P. R. China |
| Abstract: | The Onchidium genus (Mollusca, Gastropoda, Pulmonata, Systellommatophora, Onchidiidae family) is used as the important economical shellfish, due to the high nutritional value and medicinal value. Research over the previous decades indicated that Onchidium sp. mainly contains polypropionates, depsipeptides, terpenoids and other chemical components. Many biological activities of Onchidium (e. g., cytotoxic activities against tumor cells, anti-viral and anti-bacterial activities) have been reported. This review reports a total of 60 compounds, synthetic work and biological studies on Onchidium genus, covering the literature from 1978 to date, with a view to providing a reference and helping for the in-depth research of this genus. |
| Keywords: | Onchidium genus natural products secondary metabolites polypropionates biological activity |