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Eremophilane Sesquiterpenes and Benzene Derivatives from the Endophyte Microdiplodia sp. WGHS5 |
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| Authors: | Babar Khan Shuangshuang Zhao Zhiyang Wang Yonghao Ye Nasir Ahmed Rajput Wei Yan |
| Affiliation: | 1. College of Plant Protection, State and Local Joint Engineering Research Center of Green Pesticide Invention and Application, Nanjing Agricultural University, Nanjing, 210095 P. R. China Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing, 210095 P. R. China These authors contributed equally to this work.;2. College of Plant Protection, State and Local Joint Engineering Research Center of Green Pesticide Invention and Application, Nanjing Agricultural University, Nanjing, 210095 P. R. China Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing, 210095 P. R. China;3. Department of Plant Pathology, University of Agriculture, Faisalabad, 38000 Pakistan;4. College of Plant Protection, State and Local Joint Engineering Research Center of Green Pesticide Invention and Application, Nanjing Agricultural University, Nanjing, 210095 P. R. China |
| Abstract: | Three new eremophilane sesquiterpenes phomadecalins G−I ( 1 – 3 ) and two new benzene derivatives microdiplzenes A and B ( 12 and 13 ), together with nine known eremophilane sesquiterpenes ( 4 – 11 and 14 ) were isolated from an endophytic fungus, Microdiplodia sp. WGHS5. Their structures were elucidated by the interpretation of HR-ESI-MS and NMR data; meanwhile, the absolute configurations of new compounds were determined on the base of ECD calculations. All compounds were evaluated for the antimicrobial activities and antiproliferative effect on human gastric cancer cell lines (BGC-823). |
| Keywords: | eremophilane sesquiterpenes benzene derivatives Microdiplodia ECD calculations antiproliferative effect |