Chemical Composition of Magonia pubescens Essential Oils and Gamma-Radiation Effects on Its Constituents and Cytotoxic Activity in Leukemia and Breast Cancer Model |
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| Authors: | Acácio R A Moraes Karen C Camargo Maria O M Simões Vany P Ferraz Márcio T Pereira Fernanda C G Evangelista Adriano P Sabino Lucienir Pains Duarte Antônio F C Alcântara Grasiely F de Sousa |
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| Institution: | 1. Universidade Federal de Minas Gerais, Instituto de Ciência Exatas, Departamento de Química, Av. Pres. Antônio Carlos, 6627 Pampulha, CEP 31270-901 Belo Horizonte, MG, Brazil;2. Universidade Estadual de Montes Claros, Departamento de Biologia Geral, Av. Ruy Braga, CEP 39400-000 Montes Claros, MG, Brazil;3. Centro de Desenvolvimento da Tecnologia Nuclear, Av. Pres. Antônio Carlos, 6627 Pampulha, CEP 31270-901 Belo Horizonte, MG, Brazil;4. Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Av. Pres. Antônio Carlos, 6627 Pampulha, CEP 31270-901 Belo Horizonte, MG, Brazil |
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| Abstract: | Magonia pubescens A. St.-Hil. is a Brazilian species often used in ethnopharmacology for wound and pain healing and seborrhea treatment. For the first time, essential oils (EOs) obtained from M. pubescens inflorescences were studied. The plant materials (Montes Claros, Brazil, 2018) were submitted to different gamma-radiation doses and their chemical compositions were analyzed by GC/MS and GC-FID. The cytotoxic activity of the EOs was evaluated against K562 and MDA-MB-231 cancer cell lines. A total of 30 components were identified, being 24 compounds detected for the first time in M. pubescens. The main obtained components were hotrienol (35.9 %), cis-linalool oxide (17.0 %) and trans-linalool oxide (10.2 %). The chemical composition of the EO was slightly affected by the applied radiation doses. Irradiated and non-irradiated EOs showed cytotoxic activity against both cell lines and the non-irradiated EO sample was the most active against the K562 cell lines (IC50=22.10±1.98). |
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| Keywords: | Magonia pubescens Sapindaceae cytotoxicity essential oils gamma-radiation |
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