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Platanic Acid-Aryl Enones as Potential Anticancer Compounds: Synthesis and Biological Profiling against Breast,Prostate and Lung Cancer Cell Lines |
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| Authors: | Bilal Ahmad Ganaie Mir Shahid Auqib Rashid Tabassum Ara Javid Ahmad Banday Fayaz Malik Bilal A Bhat |
| Institution: | 1. National Institute of Technology, Hazratbal, Srinagar, 190006 India
CSIR-Indian Institute of Integrative Medicine, Jammu & Kashmir, 190005 India;2. CSIR-Indian Institute of Integrative Medicine, Jammu & Kashmir, 190005 India Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002 India;3. CSIR-Indian Institute of Integrative Medicine, Jammu & Kashmir, 190005 India;4. National Institute of Technology, Hazratbal, Srinagar, 190006 India |
| Abstract: | A series of rationally designed platanic acid-based compounds derived from naturally occurring betulinic acid were synthesized through a sequence of Lemieux-Johnson oxidation and Aldol condensation reaction. All the compounds were screened for cytotoxicity against a panel of human cancer and normal cell lines using MTT assay. From the biological data, it was observed that some of these semi-synthetic congeners exhibited potent biological profiles compared to platanic acid. One of the compounds with the p-tolyl substitution was found to be most active in this study, and its cytotoxicity against two of the cell lines, MDA-MB 231 and A-549 were in tune with the standard compound, 5-fluorouracil. |
| Keywords: | platanic acid arylenones cytotoxicity Aldol condensation Lemieux-Johnson oxidation |