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4,21-Secovincanol,a Novel Immunosuppressive Monoterpenoid Indole Alkaloid from Kopsia Hainanensis |
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| Authors: | Lu Liu Ting He Ya-Ping Liu Jian-Xin Cao Gui-Guang Cheng |
| Affiliation: | 1. Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, 650500 P. R. China Yunnan Key Laboratory of Southern Medicinal Resource, Yunnan University of Chinese Medicine, Kunming, 650500 P. R. China These authors contributed equally to this work.;2. Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, 650500 P. R. China These authors contributed equally to this work.;3. Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, 650500 P. R. China |
| Abstract: | 4,21-Secovincanol ( 1 ), a novel C-21/N-4 cleavage monoterpenoid indole alkaloid, along with four analogs ( 2 – 5 ), were obtained from the aerial parts of Kopsia hainanensis. Structurally, compound 1 might be a derivative of epivincanol ( 2 ) via C-21/N-4 cleavage. Their structures were confirmed by means of comprehensive spectroscopic data analysis and comparison with the reported data. All isolates significantly inhibited Con A-stimulated mice splenocytes proliferation at 10–40 μM in a dose-dependent manner in vitro. Especially, compound 3 exhibited potent activities comparable to positive control (Dexamethasone, DXM). |
| Keywords: | Kopsia hainanensis 4,21-secovincanol immunosuppressive activity monoterpenoid indole alkaloid |