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Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L. |
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| Authors: | Min Fan Ting Wang Li-Yan Peng Jun-Shang Huang Xing-De Wu He-Yao Wang Qin-Shi Zhao |
| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204 P. R. China College of Pharmacy, Dali University, Dali, 671000 P. R. China These authors contributed equally to this work.;2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 P. R. China These authors contributed equally to this work.;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204 P. R. China;4. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 P. R. China |
| Abstract: | A new neo-clerodane diterpenoid, salvihispin H ( 1 ), and six known ones ( 2 – 7 ) were identified from the aerial parts of Salvia hispanica L. The structure and absolute configuration of 1 were elucidated by extensive analysis of spectroscopic (1H, 13C, and 2D NMR, and HR-ESI-MS) and single-crystal X-ray diffraction data. The anti-diabetic effects of salvihispin H ( 1 ) and salvifaricin ( 2 ) were evaluated in diabetic db/db mice. The data showed that 1 and 2 could significantly reduce fasting blood glucose level and improve insulin resistance, and compound 1 exerted glucose-lowering effect more quickly than metformin. In addition, 1 and 2 could also reduce serum TG level in db/db mice. These results demonstrated that compounds 1 and 2 could be considered as potent candidates for the therapy of type 2 diabetes mellitus (T2DM). |
| Keywords: | Salvia hispanica neo-clerodane diterpenoid salvihispin H type 2 diabetes mellitus |