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Chemical Composition,Antibacterial Screening and Cytotoxic Activity of Chiliadenus antiatlanticus (Asteraceae) Essential Oil |
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| Authors: | Mohamed El Yaagoubi Sergio Ortiz Hicham Mechqoq Carlos Cavaleiro Marylin Lecsö-Bornet Maria João Rodrigues Luísa Custódio Abdelhamid El Mousadik Raphaël Grougnet Noureddine El Aouad Fouad Msanda Marina Kritsanida |
| Institution: | 1. Laboratory of Biotechnologies and Valorization of Natural Resources, Faculty of Sciences, University Ibn Zhor, 80060 Agadir, Morocco;2. Natural products, Analysis, Synthesis, UMR CNRS 8038 CiTCoM, Faculty of Pharmacy, University of Paris, 75006 Paris, France;3. Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Health Sciences Campus, Azinhaga de S. Comba, 3000-548 Coimbra, Portugal
Chemical Process Engineering and Forest Products Research Center, Universidade de Coimbra, Rua Sílvio Lima, Polo II, 3030-790 Coimbra, Portugal;4. Center of Marine Sciences, Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal;5. Laboratory of Biotechnologies and Valorization of Natural Resources, Faculty of Sciences, University Ibn Zhor, 80060 Agadir, Morocco Research Team on Biological Engerineering, Agrifood and Aquaculture, Polydisciplinary Faculty of Larache, University Abdelmalek Essaadi, Tétouan, Route de Rabat, 92000 Larache, Morocco |
| Abstract: | The chemical composition and in vitro antibacterial and cytotoxic activities of the essential oil (EO) of Chiliadenus antiatlanticus (Emb. & Maire) Gómiz, an asteraceous species endemic to the southwest of Morocco, were investigated. The EO yield was 1.07±0.28 %, twenty-seven metabolites were identified representing more than 96.4 % of the total composition. Camphor (35.7 %) and derivatives, borneol (4.9 %) and camphene (4.2 %) together with intermedeol (19.9 %), α-pinene (15.5 %) and (E)-pinocarveol (4.1 %) were the major constituents. An antibacterial activity was noticed against 24 strains (all Gram-positive) out of 71 at MICs values=100 μg/mL. The EO also showed significant toxicity towards liver HepG2 (55.8 % of cell viability) and melanoma B16 4A5 (41.6 % of cell viability) tumor cell lines at 100 μg/mL. |
| Keywords: | Chiliadenus antiatlanticus essential oil camphor intermedeol antibacterial activity |