The Cosmic Silence experiment: on the putative adaptive role of environmental ionizing radiation |
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Authors: | M C Carbone M Pinto F Antonelli F Amicarelli M Balata M Belli L Conti Devirgiliis L Ioannucci S Nisi O Sapora L Satta Giustina Simone E Sorrentino M A Tabocchini |
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Institution: | 1. Museo Storico della Fisica e Centro Studi e Ricerche “Enrico Fermi”, Rome, Italy 2. INFN, Gr.coll. Sanità, Sezione di Roma1, Rome, Italy 4. Department of Basic and Applied Biology, L’Aquila University, L’Aquila, Italy 5. Istituto Nazionale di Fisica Nucleare (INFN), Gran Sasso National Laboratory, Assergi, L’Aquila, Italy 3. Technology and Health Department, Istituto Superiore di Sanità (ISS), Viale Regina Elena 299, 00161, Rome, Italy 6. Environment and Primary Prevention Department, Istituto Superiore di Sanità (ISS), Rome, Italy 7. INFN, Frascati National Laboratory, Frascati, Italy
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Abstract: | Previously we reported that yeast and Chinese hamster V79 cells cultured under reduced levels of background environmental
ionizing radiation show enhanced susceptibility to damage caused by acute doses of genotoxic agents. Reduction of environmental
radiation dose rate was achieved by setting up an underground laboratory at Laboratori Nazionali del Gran Sasso, central Italy.
We now report on the extension of our studies to a human cell line. Human lymphoblastoid TK6 cells were maintained under identical
in vitro culture conditions for six continuous months, at different environmental ionizing radiation levels. Compared to “reference”
environmental radiation conditions, we found that cells cultured in the underground laboratories were more sensitive to acute
exposures to radiation, as measured both at the level of DNA damage and oxidative metabolism. Our results are compatible with
the hypothesis that ultra-low dose rate ionizing radiation, i.e. environmental radiation, may act as a conditioning agent
in the radiation-induced adaptive response. |
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