The specific expression of tenascin in the synovial membrane of the temporomandibular joint with internal derangement: An immunohistochemical study |
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| Authors: | H Yoshida Shigeyuki Fujita Tadahiko Iizuka Toshimichi Yoshida Teruyo Sakakura |
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| Institution: | (1) Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kyoto University, 54, Syogoin, Kawahara-cho, Sakyo-ku, Kyoto-shi 606, Japan Tel. +81–75–751–3405; Fax +81–75–761–9732, JP;(2) Department of Pathology, School of Medicine, Mie University, 2–174, Edobashi, Tsu-shi, Mie 514, Japan, JP |
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| Abstract: | The expression of tenascin (TN) in the temporomandibular joint (TMJ) disc and synovial membrane was examined in 18 human
TMJ samples from patients with internal derangement of the TMJ and ten control specimens by an immunohistological technique
using paraffin-embedded tissue and specific anti-human TN monoclonal antibody (RCB-1). The expression of TN was observed in
all 28 samples, but it was limited to the walls of blood vessels, the perineurium, and the surface of the TMJ disc. The expression
of TN was diffuse in the stroma of mildly hypertrophic synovial membranes and focal in the surface of severely hypertrophic
synovial membranes. The clinical symptoms of internal derangement of the TMJ are thought to be related to the degree of synovitis.
The present study demonstrates that TN is expressed specifically in the portion of the TMJ synovial membrane affected with
internal derangement.
Accepted: 17 December 1996 |
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