Haploid embryonic stem cells and the dominance of recessive traits |
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| Authors: | Schimenti John |
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| Institution: | Center for Vertebrate Genomics, Cornell University, Ithaca, NY 14850, USA. jcs92@cornell.edu |
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| Abstract: | Diploidy, though essential for normal development, is a foil to geneticists. Two recent studies (Elling et?al., 2011, this issue of Cell Stem Cell; Leeb and Wutz, 2011, Nature), report the isolation of haploid pluripotent mouse ESCs, thus enabling efficient functional screening for genes involved in diverse cellular and developmental processes. |
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