Antimicrobial breakpoint estimation accounting for variability in pharmacokinetics |
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Authors: | Denis Gohore Goue Bi Jun Li Fahima Nekka |
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Affiliation: | 1. Faculté de Pharmacie, Université de Montréal, Montréal, Québec, Canada 2. Centre de Recherche Mathématiques, Université de Montréal, Montréal, Québec, Canada 3. Pharsight, Montréal, Québec, Canada 4. Groupe de recherche universitaire sur le médicament (GRUM), Université de Montréal, Montréal, Québec, Canada
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Abstract: | Background Pharmacokinetic and pharmacodynamic (PK/PD) indices are increasingly being used in the microbiological field to assess the efficacy of a dosing regimen. In contrast to methods using MIC, PK/PD-based methods reflect in vivo conditions and are more predictive of efficacy. Unfortunately, they entail the use of one PK-derived value such as AUC or Cmax and may thus lead to biased efficiency information when the variability is large. The aim of the present work was to evaluate the efficacy of a treatment by adjusting classical breakpoint estimation methods to the situation of variable PK profiles. |
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