DNA triplex stabilization by a delta-carboline derivative tethered to third strand oligonucleotides |
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| Authors: | Todorović Nina Phuong Nguyen Thi Bich Langer Peter Weisz Klaus |
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| Institution: | 1. Proteomics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India;2. Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, India;3. CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India;1. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia;2. Department of Hepatopancreatobiliary and Regenerative Surgery, Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Trubetskaya Street 8/2, 119991 Moscow, Russia |
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| Abstract: | A delta-carboline derivative was covalently coupled to a 7 mer oligonucleotide at its 5'- or 3'-end. The stability of triplexes formed from the conjugates and a double-helical target was studied by UV melting experiments. Compared to the unmodified control triple helices, triplexes with the conjugate exhibit a significantly higher stability. However, the degree of stabilization depends on the particular triplex structure formed. |
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