Application of adeno-associated viral vectors in behavioral research |
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Authors: | Nair Hemanth P Young Larry J |
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Affiliation: | Center for Behavioral Neuroscience and Department of Psychiatry and Behavioral Neuroscience, 954 Gatewood Drive,Yerkes Research Centre, Emory University, Atlanta, GA 30322, USA. |
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Abstract: | Viral vectors afford the capability of genetically manipulating the expression of neurotransmitters, neuropeptides, hormones, and their receptors in specific brain sites of adult animals of any species. Hence, they are a powerful tool for investigating the neurochemistry underlying complex cognitive processes and behaviors. Here we discuss how the recombinant adeno-associated virus (rAAV) can be engineered for use in neurobehavioral studies, techniques for site-specific delivery of vector into the brain, characterization of expression profiles, and biosafety issues. Finally, we discuss issues of experimental design and interpretation of behavioral results in viral vector studies. |
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