Immunochemical examinations of cytochrome P-450 in various tissues of human fetuses using antibodies to human fetal cytochrome P-450, P-450 HFLa |
| |
| Authors: | M Kitada T Kamataki K Itahashi T Rikihisa R Kato Y Kanakubo |
| |
| Affiliation: | 1. Social and Epidemiological Research Department, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada;2. Institute of Medical Science, University of Toronto, Faculty of Medicine, Medical Sciences Building, 1 King''s College Circle, Toronto, ON M5S 1A8, Canada;3. Epidemiological Research Unit, Klinische Psychologie and Psychotherapie, Technische Universität Dresden, Chemnitzer Str. 46. 01187 Dresden, Germany;4. Institut de Santé Publique d''Épiémiologie et de Développement, l''Université Bordeaux Segalen, 146 Rue Léo Saignat, 33076 Bordeaux cedex, France;5. Dalla Lana School of Public Health, University of Toronto, 155 College St, Toronto, ON M5T 3M7, Canada;6. Factor-Inwentash Faculty of Social Work, University of Toronto, 246 Bloor Street W., Toronto, ON M5S 1V4, Canada;1. Division of Emergency Medicine, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH;2. Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH;3. Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH;4. Department of Family and Community Medicine, University of Arizona, Tucson, AZ |
| |
| Abstract: | P-450 HFLa is a form of cytochrome P-450 purified from human fetal livers. The amounts of P-450 HFLa in several fetal tissues were determined immunochemically. Detectable amounts presented in livers, kidneys, adrenals, lungs and some other tissues of human fetuses. The amounts were the highest in livers. Activities of 7-ethoxycoumarin O-deethylase and benzo(a)pyrene hydroxylase in livers but not in adrenals were inhibited by the anti-P-450 HFLa antibodies, probably suggesting that distinct forms of cytochrome P-450 are responsible for the oxidations in livers and adrenals. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
