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Synthesis and Antiproliferative Activity of Some Thiazolylbenzimidazole-4,7-diones |
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| Authors: | Laura Garuti Marinella Roberti Annalisa Pession Emanuela Leoncini Silvana Hrelia |
| Affiliation: | a Department of Pharmaceutical Science, University of Bologna, via Belmeloro 6, I-40126, Bologna, Italy b Department of Experimental Pathology, University of Bologna, via S. Giacomo, Bologna, Italy c Department of Biochemistry “G. Moruzzi” University of Bologna, via Irnerio48, I-40126, Bologna, Italy |
| Abstract: | Some thiazolylbenzimidazole-4,7-diones were synthesized and tested in vitro on two tumor cell lines. Compounds 2d and 2e show a very good activity on K562 cells, whereas compounds 2a and 2b are active on SW620 cells. The importance of the methoxy group on the quinone moiety is confirmed and the function at 4-position of the thiazole ring plays a determining role for the activity. |
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