Pseudomonas aeruginosa tssC1 links type VI secretion and biofilm-specific antibiotic resistance |
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| Authors: | Zhang Li Hinz Aaron J Nadeau Jean-Paul Mah Thien-Fah |
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| Affiliation: | Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Room 4125, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5. |
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| Abstract: | Biofilm-specific antibiotic resistance is influenced by multiple factors. We demonstrated that Pseudomonas aeruginosa tssC1, a gene implicated in type VI secretion (T6S), is important for resistance of biofilms to a subset of antibiotics. We showed that tssC1 expression is induced in biofilms and confirmed that tssC1 is required for T6S. |
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