The Biology of Kaposi's Sarcoma-Associated Herpesvirus and the Infection of Human Immunodeficiency Virus |
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摘 要: |
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关 键 词: | 生物学 卡波西氏肉瘤 疱疹病毒 免疫缺陷 临床分析 |
收稿时间: | 30 July 2008 |
The Biology of Kaposi's Sarcoma-Associated Herpesvirus and the Infection of Human Immunodeficiency Virus |
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Authors: | Di Qin Chun Lu |
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Institution: | Laboratory of Molecular Virology, Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, China |
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Abstract: | Kaposi sarcoma-associated herpesvirus (KSHV),also known as human herpesvirus 8 (HHV-8),is discovered in 1994 from Kaposi's sarcoma (KS) lesion of an acquired immunodeficiency syndrome (AIDS)patient.In addition to its association with KS,KSHV has also been implicated as the causative agent of two other AIDS-associated malignancies:primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD).KSHV is a complex DNA virus that not only has the ability to promote cellular growth and survival for tumor development,but also can provoke deregulated angiogenesis,inflammation,and modulate the patient's immune system in favor of tumor growth.As KSHV is a necessary but not sufficient etiological factor for KS,human immunodeficiency virus (HIV) is a very important cofactor.Here we review the basic information about the biology of KSHV,development of pathogenesis and interaction between KSHV and HIV. |
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Keywords: | Kaposi sarcoma-associated herpesvirus (KSHV) Biology Pathogenesis HIV |
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