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The discovery of long acting beta2-adrenoreceptor agonists |
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| Authors: | Brown Alan D Bunnage Mark E Glossop Paul A James Kim Jones Rhys Lane Charlotte A L Lewthwaite Russell A Mantell Simon Perros-Huguet Christelle Price David A Trevethick Mike Webster Rob |
| Affiliation: | Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. |
| Abstract: | The design and profile of a series of saligenin containing long acting beta(2)-adrenoreceptor agonists is described. Evaluation of these analogues using a guinea-pig tissue model demonstrates that analogues within this series have significantly longer durations of action than salmeterol and have the potential for a once daily profile in human. |
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