Suppression of heat-induced HSP-70 by simultaneous exposure to 50 mT magnetic field |
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Authors: | Miyakoshi J Mori Y Yaguchi H Ding G Fujimori A |
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Institution: | Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Japan. miyakosh@mfour.med.kyoto-u.ac.jp |
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Abstract: | Effect of extremely low frequency magnetic field (ELFMF) at 50 mT and 60 Hz on heat-induced expression of heat shock protein 70 (hsp-70) was examined in HL60RG cells. No increase in hsp-70 production was observed in the cells after exposure to 50 mT ELFMF alone. Simultaneous exposure to 50 mT ELFMF in combination with mild heat at 42 and 40 degrees C suppressed heat-induced hsp-70 expression. The suppression of hsp-70 occurred when cells were simultaneously exposed to both for longer periods of more than 5 h. However, the suppression of hsp-70 was not observed at a magnetic density of 5 and 0.5 mT. This result suggests that exposure to 50 mT ELFMF may act on a protection against the concomitant mild heat stress in HL60RG cells. |
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