Spatial relational memory requires hippocampal adult neurogenesis |
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Authors: | Dupret David Revest Jean-Michel Koehl Muriel Ichas François De Giorgi Francesca Costet Pierre Abrous Djoher Nora Piazza Pier Vincenzo |
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Affiliation: | INSERM U862, Institut F. Magendie, Bordeaux, France. |
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Abstract: | The dentate gyrus of the hippocampus is one of the few regions of the mammalian brain where new neurons are generated throughout adulthood. This adult neurogenesis has been proposed as a novel mechanism that mediates spatial memory. However, data showing a causal relationship between neurogenesis and spatial memory are controversial. Here, we developed an inducible transgenic strategy allowing specific ablation of adult-born hippocampal neurons. This resulted in an impairment of spatial relational memory, which supports a capacity for flexible, inferential memory expression. In contrast, less complex forms of spatial knowledge were unaltered. These findings demonstrate that adult-born neurons are necessary for complex forms of hippocampus-mediated learning. |
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