Free energy transduction in a chemical motor model |
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Authors: | Baker Josh E |
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Affiliation: | Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA. jbaker@physiology.med.uvm.edu |
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Abstract: | Motor enzymes catalyse chemical reactions, like the hydrolysis of ATP, and in the process they also perform work. Recent studies indicate that motor enzymes perform work with specific biochemical steps in their catalysed reactions, challenging the classical view that work can only be performed within a biochemical state. To address these studies an alternative class of models, often referred to as chemical motor models, has emerged in which motors perform work with biochemical transitions. In this paper, I develop a novel, self-consistent framework for chemical motor models, which accommodates multiple pathways for free energy transfer, predicts rich behaviors from the simplest multi-motor systems, and provides important new insights into muscle and motor function. |
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Keywords: | Molecular motors Mechanochemical coupling Energetics Thermodynamics |
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