Effect of gastrointestinal tract secretions on the anti-lysozyme activity of enterobacteria

The effect of the duodenal contents and its components on the antilysozyme activity (ALA) of enterobacteria was studied. Under the action of native bile and the preparation of dried bile the stimulation of the expression of ALA factor in 86.6-93.3% of enterobacteria was observed. Pancreatin increased the level of the secretion of ALA factor by 50% in comparison with the control. The preparation of egg lysozyme produced no changes in the frequency and level of the expression of ALA factor. The study revealed the dose-dependant character of the action of duodenal contents: in the native form, as well as at concentrations of 50% and 25%, duodenal contents stimulated the expression of the ALA factor of enterobacteria; at concentrations of 12.5% and lower, its effect could be stimulating, inhibitory or neutral.