Conformational analysis of amino acids and peptides using specific isotope substitution. I. Conformation of L-phenylalanylglycine. |
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| Authors: | M Kainosho K Ajisaka M Kamisaku A Murai Y Kyogoku |
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| Affiliation: | Central Research Laboratories, Ajinomoto Co. Ltd., 1-1 Suzukicho, Kawasaki, 210, Japan;Institute for Protein Research, Osaka University, Yamadakami, Suita, Osaka, 565, Japan |
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| Abstract: | L-Phenylalanyl-(R)-[2H]glycine, L-valyl-(R)-[2H]glycine, and L-phenylalanyl [15N]glycine were prepared. Assignments for pro-R and pro-S proton NMR signals of the glycine residue were done and coupling constants between proton and 15N were obtained. Based on the data an attempt to explain the origin of the nonequivalence of the glycine methylene protons was made, and a conformational model for L-phenylalanylglycine is proposed. |
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