Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents |
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Authors: | Kumar Atul Pathak S R Ahmad Pervez Ray S Tewari P Srivastava A K |
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Affiliation: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. dratulsax@gmail.com |
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Abstract: | A series of aminoalkoxy phenyl-substituted naphthalene-1-yl-methanone was synthesized and tested for its anti-hyperglycemic activity in SLM and STZ-S rat models. Some compounds (3b, 4c and 4h) of the series were showing significant anti-hyperglycemic activity in male Sprague-Dawley rats in sucrose-loaded model (SLM) as well as in streptozotocin-induced model (STZ-S). Active compounds were also evaluated for relative binding affinity against glucagon receptor. |
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