(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production |
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| Authors: | Hu Lain-Yen Du Daniel Hoffman Jennifer Smith Yvonne Fedij Victor Kostlan Catherine Johnson Theodore R Huang Yun Kesten Steve Harter William Yue Wen Song Li Jie Jack Barvian Nicole Mitchell Lorna Lei Huangshu John Lefker Bruce Carroll Mathew Dettling Danielle Krieger-Burke Teresa Samas Brian Yalamanchili Radhika Lapham Kimberly Pocalyko David Sliskovic Drago Ciotti Susan Stoller Brenda Hena Mostofa A Ding Qizhu Maiti Samarendra N Stier Michael Welgus Howard |
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| Affiliation: | Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. lain-yen.hu@pfizer.com |
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| Abstract: | Synthesis, pharmacology, and pharmacokinetic profiles of (1R, 2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile are reported. This compound demonstrated remarkable potency for stimulating hair growth in a male C3H mouse model as well as reducing sebum production in the male Syrian hamster ear model. |
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