Pathoadaptive mutations: gene loss and variation in bacterial pathogens. |
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| Authors: | E V Sokurenko D L Hasty D E Dykhuizen |
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| Affiliation: | Dept of Microbiology, University of Washington, Seattle, WA 98195, USA.evs@u.washington.edu |
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| Abstract: | Pathogenicity-adaptive, or pathoadaptive, mutations represent a genetic mechanism for enhancing bacterial virulence without horizontal transfer of specific virulence factors. Pathoadaptive evolution can be important within single infections and for defining the population structure of a pathogenic species. |
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