The complex of poly(dG).poly(dC) with arginine: stabilization of the B form and transition to multistranded structures |
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Authors: | J L Campos J A Subirana |
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Affiliation: | Unidad Quimica Macromolecular del C.S.I.C. Escuela T.S. de Ingenieros Industriales, Barcelona, Spain. |
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Abstract: | We have studied by X-ray diffraction fibers of complexes of poly(dG).poly(dC) with N-alpha-acetyl-L-arginine ethylamide. Although these polynucleotides favour the A form of DNA, in this complex it is never found, thus confirming that arginine prevents the appearance of this form of DNA. At high relative humidity the B form is present. Upon dehydration two new structures appear. One of them is a triple helix, most likely formed by poly(dC+).poly(dG).poly(dC). The other structure found also has features which indicate a multistranded conformation. |
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