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Generation of cloned transgenic pigs rich in omega-3 fatty acids |
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| Authors: | Lai Liangxue Kang Jing X Li Rongfeng Wang Jingdong Witt William T Yong Hwan Yul Hao Yanhong Wax David M Murphy Clifton N Rieke August Samuel Melissa Linville Michael L Korte Scott W Evans Rhobert W Starzl Thomas E Prather Randall S Dai Yifan |
| Institution: | Division of Animal Science, University of Missouri-Columbia, Columbia, Missouri 65211, USA. |
| Abstract: | Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001). |
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