Evolutionary history of selenocysteine incorporation from the perspective of SECIS binding proteins |
| |
| Authors: | Jesse Donovan and Paul R Copeland |
| |
| Institution: | (1) Department of Molecular Genetics, Microbiology, and Immunology, Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ, USA |
| |
| Abstract: | Background The co-translational incorporation of selenocysteine into nascent polypeptides by recoding the UGA stop codon occurs in all
domains of life. In eukaryotes, this event requires at least three specific factors: SECIS binding protein 2 (SBP2), a specific
translation elongation factor (eEFSec), selenocysteinyl tRNA, and a cis -acting selenocysteine insertion sequence (SECIS) element in selenoprotein mRNAs. While the phylogenetic relationships of
selenoprotein families and the evolution of selenocysteine usage are well documented, the evolutionary history of SECIS binding
proteins has not been explored. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
