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Cleavage of Armadillo/beta-catenin by the caspase DrICE in Drosophila apoptotic epithelial cells |
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| Authors: | Thomas Kessler H Arno J Müller |
| Affiliation: | 2. Institut für Genetik, Heinrich Heine Universit?t, Düsseldorf, Germany 3. Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany 1. Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, Scotland, UK |
| Abstract: | BackgroundDuring apoptosis cells become profoundly restructured through concerted cleavage of cellular proteins by caspases. In epithelial tissues, apoptotic cells loose their apical/basal polarity and are extruded from the epithelium. We used the Drosophila embryo as a system to investigate the regulation of components of the zonula adherens during apoptosis. Since Armadillo/beta-catenin (Arm) is a major regulator of cadherin-mediated adhesion, we analyzed the mechanisms of Arm proteolysis in apoptosis. |
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