Developmental Profiles of Lipogenic Enzymes and Their Regulators in the Neonatal Mouse Brain |
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Authors: | Mariko Saito Goutam Chakraborty Rui-Fen Mao Csaba Vadasz Mitsuo Saito |
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Institution: | (1) Laboratory of Neurobehavior Genetics, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd., Orangeburg, NY 10962, USA;(2) Division of Analytical Psychopharmacology, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA;(3) Department of Psychiatry, New York University Langone Medical Center, New York, NY 10016, USA |
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Abstract: | It has been shown that lipogenic enzymes, such as fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), are highly expressed
in the rodent brain during the early neonatal period and decline thereafter. However, cellular localization of these enzymes
is unknown. Presently, we examined developmental changes in the levels and cellular localization of FAS and ACC, and their
putative regulators, sterol-regulatory element-binding protein (SREBP)-1 and AMP-activated protein kinase (AMPK) in the mouse
brain. Levels of these proteins including phosphorylated forms of ACC and AMPK decreased between postnatal day 4 (P4) and
P19. Immunohistochemical studies indicated that FAS, ACC, AMPK, and SREBP-1 were expressed in neurons at P7, while FAS was
found mostly in cells of oligodendrocyte lineage at P19. These studies suggest that neurons in the early neonatal brain are
involved in do novo fatty acid synthesis. |
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