PH结构域与细胞方向感觉

PH（pleckstrin homology）结构域与细胞方向感觉关系密切，目前已发现，PH结构域存在于60多种蛋白质中，这些蛋白质能与趋化细胞胞膜表面的相关结合位点结合，进而激发信号转导的下游事件.这种结合有以下特点：a.迅速而短暂；b.只与外界环境中两点间浓度梯度差相关，据此提出了“空间模式”；c.改变趋化剂的位置时，结合位点在胞膜上的分布也随之改变，由此提出了“时间模式”.深入而全面地探讨各种PH结构域及其结合位点在细胞方向感觉中的作用，对于细胞方向感觉的研究具有巨大的推动作用和深远的理论意义.

PH Domain and Cell's Sense of Direction

The cell's sense direction is closely related with the proteins that contain PH (pleckstrin homology) domain. PH domain has been found in about 60 proteins, many of which could activate the sequent events of signal transduction via combining with the related binding sites on the surface of chematactic cells. The characteristics of this combining are: a.rapid and transient; b.It is only related to the concentration gradient of surroundings outside cells, which is the base of spatial model; c.The distribution of the binding sites on the cell membrane changes when the researchers altered the position of the chemoattractant. This is the base of temporal model. To deeply investigate the effects of all kinds of proteins which contain PH domain on cell's sense of direction will greatly promote the research of this field, and hence, has great theoretical significance.