Identification of arylsulfonamides as Aquaporin 4 inhibitors |
| |
| Authors: | Huber Vincent J Tsujita Mika Yamazaki Maya Sakimura Kenji Nakada Tsutomu |
| |
| Affiliation: | Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1-757 Asahi Machi Dori, Niigata 951-8585, Japan. vjhuber@bri.niigata-u.ac.jp |
| |
| Abstract: | Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 microM. Phloretin was inactive under the same conditions. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
