BRCA1, Hormone, and Tissue-Specific Tumor Suppression |
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| Authors: | Yanfen Hu |
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| Affiliation: | Department of Molecular Medicine/Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA |
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| Abstract: | Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability. |
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| Keywords: | BRCA1 tumor suppression estrogen genome instability. |
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