Synthesis and biological activities of (Z) and (E) alpha-ethenyl acyclonucleosides |
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| Authors: | Redwane N Lazrek H B Barascut J L Imbach J L Balzarini J Witvrouw M De Clercq E |
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| Affiliation: | Laboratoire de Chimie Bio-Organique, Faculté des Sciences Semlalia, Marrakech, Morocco. |
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| Abstract: | Synthesis of Z and E ethenyl acyclonucleosides (6a-e and 7a-e) via Michael addition of nucleobases with the diethyl acetylenedicarboxylate is described. The structures of compounds have been confirmed by spectral data. New compounds were found to be inactive against DNA and RNA viruses. |
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