A new method for the synthesis of N2-alkylguanosines using Mitsunobu reaction as a key step |
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| Authors: | Kozai S Yorikane A Maruyama T |
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| Affiliation: | Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan. |
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| Abstract: | Peracetylated guanosine was reacted with POCl3 to give an 2-acetamido-6-chloro-9H-purine derivative, which was condensed with primary or secondary alcohols to give N2-alkylated analogues. The products were treated with mercaptoethanol in the presence of sodium methoxide to afford N2-alkylguanosines. |
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