Galanin-like peptide gene expression in the hypothalamus and posterior pituitary of the obese fa/fa rat |
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| Authors: | Saito Jun Ozaki Yumi Kawasaki Makoto Ohnishi Hideo Okimoto Nobukazu Nakamura Toshitaka Ueta Yoichi |
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| Institution: | Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan. |
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| Abstract: | We examined the galanin-like peptide (GALP) gene expression in the arcuate nucleus (ARC) and posterior pituitary (PP) in 6- and 18-week-old male obese fa/fa rats. GALP mRNA in the ARC in fa/fa rats was significantly decreased in 6- and 18-week-old and GALP mRNA in the PP in fa/fa rats was significantly increased in 18-week-old compared to lean Fa/? rats. Insulin treatment in hyperglycemic fa/fa rats partially reversed those changes. These results suggest that the GALP gene expression in fa/fa rats might be regulated in part by leptin-independent mechanisms. |
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