Lectin Complement Protein Collectin 11 (CL-K1) and Susceptibility to Urinary Schistosomiasis |
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| Authors: | Justin S Antony Olusola Ojurongbe Peter G Kremsner Thirumalaisamy P Velavan |
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| Institution: | 1 Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany, ; 2 Ladoke Akintola University of Technology, Ogbomoso, Nigeria, ; 3 Fondation Congolaise pour la Recherche Medicale, Brazzaville, Republic of Congo, ; Centers for Disease Control and Prevention, UNITED STATES, |
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| Abstract: | BackgroundUrinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3), a member of the vertebrate C-type lectin super family, has recently been identified as pattern-recognition molecule (PRR) of the lectin complement pathway. CL-K1 is preferentially expressed in the kidneys, but also in other organs and it is considered to play a role in host defense to some infectious agents. Schistosome teguments are fucosylated and CL-K1 has, through its collagen-like domain, a high binding affinity to fucose.ConclusionsIn agreement with findings from our earlier published study, our findings support the observation that CL-K1 and their functional variants may be host factors associated with protection in schistosomiasis and may be a useful marker for further investigations. |
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