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Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia
Authors:Allon Wagner  Noa Cohen  Thomas Kelder  Uri Amit  Elad Liebman  David M Steinberg  Marijana Radonjic  Eytan Ruppin
Affiliation:1. The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel;2. Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA, USA;3. Microbiology and Systems Biology, TNO, Zeist, the Netherlands;4. Neufeld Cardiac Research Institute, Tel Aviv University, Tel Aviv, Israel;5. Regenerative Medicine Stem Cells and Tissue Engineering Center, Sheba Medical Center, Tel Hashomer, Israel;6. Department of Computer Science, University of Texas at Austin, Austin, TX, USA;7. Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv, Israel;8. The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;9. Department of Computer Science, Institute of Advanced Computer Sciences (UMIACS) & the Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA
Abstract:
Keywords:connectivity map   disease reversal   drug repositioning   homeostasis   systems medicine
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